Synapsin is an innovative, patent-pending powder blend of ginsenoside Rg3 and nicotinamide riboside along with components to aid in solubilization and dispersion. It is an ingredient designed to be used in dietary supplement formulations for the support of neurological and cognitive health. Synapsin was invented by the renowned author, pharmacist and functional medicine speaker Jim LaValle, RPh, CCN, ND, and is commonly used to support neuronal function and cognition.


  • Supports neuronal health
  • Supports NAD+ production in the central and peripheral nervous system, and supports healthy sirtuin expression
  • Supports healthy mitochondrial function
  • Supports the attenuation of microglial activation


Rg3 is one of several triterpene saponins (ginsenosides) found in the plant genus Panax, including Panax ginseng (Asian ginseng) and Panax quinquifolius (American ginseng). Laboratory studies report that Rg3 extracted from Panax ginseng supports neuroprotection, helping to support healthy microglial activity and healthy neuronal function.


Nicotinamide riboside (NR) is a form of vitamin B3 found in cow’s milk. Laboratory studies report administration of nicotinamide riboside supports healthy levels of NAD+ in yeast and cultured human and mammalian cells. NR is reported to be incorporated into the cellular NAD+ pool via the action of nicotinamide riboside kinase (Nrk) pathway or via nicotinamide (Nam) salvage after conversion to Nam by phosphorolysis. Laboratory studies have also reported the supportive and neuroprotective role for NAD+. In laboratory studies, nicotinamide riboside supports neuronal NAD+ synthesis without inhibiting sirtuins, which are important regulators of metabolism and longevity.


Is Synapsin sterile? No. Synapsin is a non-sterile powder, and it should not be used in sterile preparations.
Does Synapsin need to be refrigerated? Yes. To maintain the stability of the nicotinamide riboside.
Do Synapsin preparations require a prescription? Yes. Synapsin formulations should only be compounded and dispensed as prescribed by a health care professional.


The support of a healthy neurological function is a significant need in the marketplace. Traumatic brain injury (TBI) is a leading cause of injury, death and disability in the U.S. A 1999 CDC report to Congress estimated that 5.3 million residents in the U.S. were living with TBI-related disabilities, including long-term cognitive and psychological impairments. Globally, TBI is estimated to occur at a rate of 106 per 100,000.

According to the CDC, approximately 2.4 million traumatic brain injuries were treated in U.S. emergency rooms in 2009, with an estimated 75% occurring as concussions. Of these, approximately 16.5% are associated with sports-related injury. A study of nearly 3,000 serious head trauma cases reported that 52% of survivors were moderate to severely disabled at one-year post-accident.5 The annual economic cost of TBI in the U.S., including direct medical and rehabilitation costs and indirect societal economic costs, is estimated to be
approximately $76.5 billion.

Additionally, as we age, memory impairment is thought to be a consequence of a decline in neuronal function and increase in neurodegeneration, with oxidative stress as a major factor in brain aging and memory impairment. More than one million adults in the U.S. are diagnosed annually with chronic brain disease or disorder, with Alzheimer’s disease being the most prevalent cause of adult-onset brain disorders.

Research estimates that in the U.S., 35.8% of those 85 or older have moderate or severe memory impairment, and individuals 85 years and older are the fastest growing segment of the population.8 In 2016, it was estimated that 5.4 million Americans had Alzheimer’s disease, with Alzheimer’s and other dementias accounting for $236 billion in health care costs. By midcentury, it is projected that 14 million will have Alzheimer’s,10 with treatment and care amounting to over $1 trillion.