labratory2The technical term for mouth sores is stomatitis (an inflammation of the mucous lining of any of the structures in the mouth, which may involve the cheeks, gums, tongue, lips, throat, and roof or floor of the mouth.). This can be caused by chemotherapy, radiation, bone marrow transplant, and other conditions such as oral infection, allergy, Behcet’s Disease, or AIDS. These sores can be disabling and may interfere with speaking and eating.

Mouthwashes and rinses can be compounded to help ease the pain associated with the ulcer and, in some cases, to help prevent or cure the problem. They usually contain three or more of these types of medications; antibiotics, antifungals, anesthetics, antihistamines, antacids, and coating agents.

Many mouthwash formulations have been used over the years.

Some of the most common formulas are:

  • The Kaiser Mouthwash: Tetracycline, Nystatin, Hydrocortisone (antibiotic, antifungal, steroid)
  • Kraemer’s Mouthwash: Nystatin, Dyclonine, Glycerin (antifungal, anesthetic)
  • Powell’s Mouthwash: Tetracycline, Nystatin, Hydrocortisone, Diphenhydramine (antibiotic, antifungal, steroid, antihistamine)
  • Reynold’s Mouthwash: Tetracycline, Nystatin, Hydrocortisone, Chlorpheniramine (antibiotic, antifungal, steroid, antihistamine)
  • Stanford’s Mouthwash: Tetracycline, Nystatin, Hydrocortisone, Chlorpheniramine (antibiotic, antifungal, steroid, antihistamine)
  • Magic Mouthwash-version I: Maalox(R), Benedryl, Lidocaine (antacid, antihistamine, anesthetic)
  • Magic Mouthwash-version II: Mylanta(R), Benedryl, Sucralfate (antacid, antihistamine, anesthetic)
  • Miracle Mouthwash: Tetracycline, Nystatin, Dexamethasone, Diphenhydramine (antibiotic, antifungal, steroid, antihistamine)

Any of the above combinations can also be referred to as MAGIC MOUTHWASH or MIRACLE MOUTHWASH and they require a prescription from a physician.

DIRECTIONS FOR USE: Use approximately a tablespoonful. Keep in mouth and swish for at least 1 minute, then spit.

Don’t eat 30 minutes prior to and don’t eat or drink 30 minutes after use.
Use as often as directed by your doctor.

Quantities ordered are usually 8 ounces to a pint.

HOW TO ORDER: These mouthwashes require a prescription from a physician.

It is possible to make a non-prescription MOUTHWASH.

Information about it can be found HERE


1 Compounding Mouthwashes and Rinses for Oral Ulcerations. Int J of Pharm Comp. Jan-Feb 1999.
2 Burgess JA, Johnson BD, Sommers E. Pharmacological management of recurrent oral mucosal ulceration. Drugs 1990; 39:54-65.
3 Glick M. Muzyka BC. Alternative therapies for major aphthous ulcers in AIDS patients. JADA 1992; 123:61-65.
4 Loprinzi CL, Foote RL, Michalak J. Alleviation of cytotoxic therapy-induced normal tissue damage. Seminar in Oncology 1995; 22(Suppl 3):95-97.
5 Allen, Loyd V Jr. Stomatitis Oral Suspensions. The Complete U.S. Pharmacist Collection: Allen’s Compounded Formulations; American Pharmaceutical Association, Washington, DC. 2003; pp 314-315.


Update November 28, 2018 LJJF