Available in tablets and nasal spray
Use: As with most drugs marketed for the treatment of migraines, sumatriptan is believed to work by narrowing the blood vessels around the brain. It also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Side Effects: This drug can cause serious side effects on the heart, including heart attack or stroke. Although these side effects are rare, do not use this medication if you have a history of heart disease, angina (chest pain), blood circulation problems, ischemic bowel disease, severe or uncontrolled high blood pressure, or history of a heart attack or stroke.

Tell your doctor if you have a seizure disorder, high blood pressure, kidney or liver disease, coronary artery disease, or risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

Do not use within 24 hours before or after using almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), rizatriptan (Maxalt), naratriptan (Amerge), zolmitriptan (Zomig), or ergot medicine such as methysergide (Sansert), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

Do not use this medicine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or phenelzine (Nardil) in the past 14 days. Before using Imitrex, tell your doctor if you are also taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).

Precautions: Do not use Imitrex if you are allergic to sumatriptan, or if you have ischemic bowel disease, severe liver disease, severe high blood pressure, or a history of heart disease, angina, circulation problems, heart attack, or stroke.

Directions: This medication is used as needed; it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using it. After taking a tablet, you must wait two (2) hours before taking a second tablet. Do not take more than 200 mg tablets in 24 hours. After using nasal spray, you must wait two (2) hours before using a second spray. Do not use more than 40 mg of the nasal spray in 24 hours. Keep out of reach of children and pets